Search results for "C - H"
showing 7 items of 7 documents
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
2020
Adult hippocampal neurogenesis was originally discovered in rodents. Subsequent studies identified the adult neural stem cells and found important links between adult neurogenesis and plasticity, behavior, and disease. However, whether new neurons are produced in the human dentate gyrus (DG) during healthy aging is still debated. We and others readily observe proliferating neural progenitors in the infant hippocampus near immature cells expressing doublecortin (DCX), but the number of such cells decreases in children and few, if any, are present in adults. Recent investigations using dual antigen retrieval find many cells stained by DCX antibodies in adult human DG. This has been interprete…
Adult rat myelin enhances axonal outgrowth from neural stem cells.
2018
Axon regeneration after spinal cord injury (SCI) is attenuated by growth inhibitory molecules associated with myelin. We report that rat myelin stimulated the growth of axons emerging from rat neural progenitor cells (NPCs) transplanted into sites of SCI in adult rat recipients. When plated on a myelin substrate, neurite outgrowth from rat NPCs and from human induced pluripotent stem cell (iPSC)-derived neural stem cells (NSCs) was enhanced threefold. In vivo, rat NPCs and human iPSC-derived NSCs extended greater numbers of axons through adult central nervous system white matter than through gray matter and preferentially associated with rat host myelin. Mechanistic investigations excluded …
May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
2018
Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with…
Computer Aided Evaluation of HPLC (High Pressure Liquid Chromatography) with Fluorometric Detection
1982
A program system for automated HPLC measurements of vitamin A concentration is reported. This system provides for guidance of operators, for control of apparatus and for supervision of quality measurements.
Lesbas meliķu pēdas romiešu lirikā: maģistra darbs
1944
Crystal structure of (E)-N-(3,4-dimethoxybenzylidene)morpholin-4-amine
2014
In the title compound, C13H18N2O3, the benzene ring makes a dihedral angle of 17.19 (11)° with the least-squares plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation. In the crystal, C—H...N hydrogen bonds link the molecules into supramolecular chains running along a 21screw axis parallel to theb-axis direction. Weak C—H...π interactions are also observed.
Three phenanthroline-metal complexes with topologically similar but geometrically different conformations.
2016
Two out of the three very similar complexes described present twofold symmetry but not the third one, probably by way of a strong intramolecular C—H⋯O hydrogen bond disrupting the symmetry, a fact which is analysed in detail.